Post Doctoral Research Trainee, Bioengineering-Biomechanics Laboratory, The Feinstein Institute for Medical Research
Phone: (516) 562-2534
Email: rmaidhof@nshs.edu
Dr. Robert Maidhof is a post doctoral research trainee at the Feinstein Institute for Medical Research, where he is studying the mechanisms of intervertebral disc degeneration under the direction of Dr. Nadeen Chahine in the Bioengineering-Biomechanics Lab. Robert obtained his undergraduate degree from Columbia University (2005) and completed his PhD at Columbia University in the Laboratory for Cell and Tissue Engineering under the direction of Gordana Vunjak-Novakovic (2010).
Dr. Maidhof’s research is focused on degeneration of the intervertebral disc, which is a major contributing factor to lower-back pain. He is working to elucidate the underlying cellular mechanisms of disc degeneration in an effort to understand the disease process and develop novel targeted therapeutics to restore function.
In the lab, Dr. Maidhof uses rigorous tools of bioengineering, cellular and molecular biology, and animal disease models to characterize the function of healthy and diseased tissues. His approach involves research at the joint, tissue, cellular, and molecular levels to understand the disease process and test novel therapeutic approaches. The ultimate goal is to develop treatments, and potentially cures, for degenerative disc disease.
Columbia University, New York, NY
Degree: BS
2005
Field of Study: Biomedical Engineering
Columbia University, New York, NY
Degree: MS
2007
Field of Study: Biomedical Engineering
Columbia University, New York, NY
Degree: MPh
2009
Field of Study: Biomedical Engineering
Columbia University, New York, NY
Degree: PhD
2010
Field of Study: Biomedical Engineering
2007 NIH Cardiac molecular training fellowship
2012 Philadelphia Spine Symposium ; best presentation award
- Maidhof R., Jacobsen T., Chahine NO. “Inflammation induces irreversible changes on osmotic properties of isolated nucleus pulposus cells.” (in preparation)
- Maidhof R., Alipui DO., Rafiuddin A., Levine M., Grande DA., Chahine NO. ”Emerging Trends in Biological Therapy for Intervertebral Disc Degeneration.” Discov Med. 2012 Dec;14(79).
- Marsano A., Maidhof R., Luo J., Fujikara K., Konofagou E.E., Banfi A., Vunjak-Novakovic G. “The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction.” Biomaterials. 2013 Jan;34(2).
- Rajan N., Bloom O., Maidhof R., Stetson N., Sherry B., Levine M., Chahine NO. “Toll-like receptor 4 (TLR4) expression and stimulation in a model of intervertebral disc inflammation and degeneration.” Spine, 2012.
- Maidhof R., Tandon N., Lee EJ., Luo J., Duan Y., Yeager K., Vunjak-Novakovic G., “Biomimetic perfusion and electrical stimulation applied in concert improve the in vitro assembly of engineered cardiac tissue.” J Tissue Eng and Regen Med, 2011.
- Zhang T., Wan L.Q., Xiong Z., Marsano A., Maidhof R., Park M., Yan Y., Vunjak-Novakovic G. “Channeled scaffolds for engineering myocardium with mechanical stimulation.” J Tissue Eng Regen Med, 2011
- Maidhof R., Marsano A., Lee EJ., Vunjak-Novakovic G. ”Perfusion seeding of channeled elastomeric scaffolds with myocytes and endothelial cells for cardiac tissue engineering.” Biotech Prog, 26(2), 565, 2010.
- Maidhof R.*, Marsano A.*, Wan L., Wang Y., Gao J., Tandon N., Vunjak-Novakovic G. “Scaffold stiffness affects the contractile functionality of engineered cardiac constructs.” Biotech Prog 26(5), 1382, 2010.
- Tandon N., Marsano A., Maidhof R., Numata, K. Montouri-Sorrentino, C., Cannizzaro C., Voldman J., Vunjak-Novakovic G. “Surface-patterned electrode bioreactor for electrical stimulation.” Lab Chip 10(6), 692, 2010.
- Vunjak-Novakovic G., Tandon N., Godier A., Maidhof R., Marsano A., Martens T., Radisic M. “Challenges in cardiac tissue engineering.” Tissue Eng Part B Rev 16(2), 169, 2010.
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