Assistant Investigator, Robert S. Boas Center for Genomics and Human Genetics,
The Feinstein Institute for Medical Research
Phone: (516) 562-1151
Email: nmanjarrez@nshs.edu
Nataly Manjarrez Orduño obtained her PhD in Biomedicine at CINVESTAV, where she studied the mechanisms that regulate antibody secretion. She was a visiting scholar at UniSpital Zurich where she worked on the regulation of germinal center responses. She later did postdoctoral training on the biology of systemic lupus with Dr. Ignacio Sanz at the University of Rochester Medical Center.
Dr. Manjarrez Orduño came to the Feinstein Institute in 2009, and since then, she has performed studies at the interface of genetics and immunology. Her work aims use genetics and immunology to identify novel therapeutic targets for autoimmune diseases such as rheumatoid arthritis, systemic lupus and scleroderma.
Dr. Manjarrez Orduño work aims to use genetic information to identify therapeutic targets for autoimmune diseases that can be validated by immunological and biological assays. Her target diseases are systemic lupus erythematosus, rheumatoid arthritis and systemic scleroderma. Because her work is performed directly on human cells and tissues, the knowledge generated can be directly translated into the clinic.
Recent work includes identifying a genetic polymorphism in the CSK gene as a risk factor for the development of systemic lupus, and associating this risk polymorphism with increased activation and maturation of human B cells (Nature Genetics, 2012). A Career Development Award from the NIAMS currently funds the continuation of this work.
She has intra and extramural collaborations to evaluate the epigenome and the expression profile of immune cells.
CINVESTAV, Mexico City, Mexico
Degree: PhD
2006
Field of Study: Molecular Biomedicine
CINVESTAV, Mexico City, Mexico
Degree: MS
2002
Field of Study: Molecular Biomedicine
Universidad de Sonora, Hermosillo, Sonora, Mexico
Degree: BS
2000
Field of Study: Biological Chemist
1997-2006 Carso Foundation, Fundacion Telmex Fellowship
2005 National Academy of Medicine, Mexico. von-Behring-Kitasato fellowship for immunology students
2008-2009 National Council for Science and Technology, Mexico. Postdoctoral fellowship
2010 Federation of Clinical Immunology Societies’, travel award to attend the annual meeting
2010 Cold Spring Harbor Laboratory, travel award for the Workshop on Leadership in bioscience
2012 FASEB travel award to the Annual Meeting of the American Society of Human Genetics
2013 K-award 1K01AR063169-01A1 from the NIAMS
- Gregersen PK, Manjarrez-Orduño N. “FOXO in the hole: leveraging GWAS foroutcome and function.” Cell. 2013 Sep 26;155(1):11-2. doi: 10.1016/j.cell.2013.08.050. PubMed PMID: 24074853.
- Knevel R, Klein K, Somers K, Ospelt C, Houwing-Duistermaat JJ, van Nies JA, de Rooy DP, de Bock L, Kurreeman FA, Schonkeren J, Stoeken-Rijsbergen G, Helmer Q, van der Linden MP, Kern M, Manjarrez-Orduno N, Rodriguez-Rodriquez L, Stinissen P, Huizinga TW, Toes RE, Gay S, Gregersen PK, Somers V, van der Helm-van Mil AH. “Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis.” Ann Rheum Dis. 2013 Aug 16. doi: 10.1136/annrheumdis-2013-204050. PubMed PMID: 23956247.
- Manjarrez-Orduño N, Marasco E, Chung SA, Katz MS, Kiridly JF, Simpfendorfer KR, Freudenberg J, Ballard DH, Nashi E, Hopkins TJ, Cunninghame Graham DS, Lee AT, Coenen MJ, Franke B, Swinkels DW, Graham RR, Kimberly RP, Gaffney PM, Vyse TJ, Behrens TW, Criswell LA, Diamond B, Gregersen PK. “CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.” Nat Genet. 2012 Nov;44(11):1227-30. doi: 10.1038/ng.2439. Epub 2012 Oct 7. PubMed PMID: 23042117; PubMed Central PMCID: PMC3715052.
- Simpfendorfer KR, Olsson LM, Manjarrez Orduño N, Khalili H, Simeone AM, Katz MS, Lee AT, Diamond B, Gregersen PK. “The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development.” Hum Mol Genet. 2012 Sep 1;21(17):3918-25. doi: 10.1093/hmg/dds220. Epub 2012 Jun 7. PubMed PMID: 22678060; PubMed Central PMCID: PMC3412385.
- Quách TD, Manjarrez-Orduño N, Adlowitz DG, Silver L, Yang H, Wei C, Milner EC, Sanz I. “Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.” J Immunol. 2011 Apr 15;186(8):4640-8. doi: 10.4049/jimmunol.1001946. Epub 2011 Mar 11. PubMed PMID: 21398610; PubMed Central PMCID: PMC3095097.
- Manjarrez-Orduño N, Quách TD, Sanz I. “B cells and immunological tolerance.” J Invest Dermatol. 2009 Feb;129(2):278-88. doi: 10.1038/jid.2008.240. Review. PubMed PMID: 19148217; PubMed Central PMCID: PMC2728045.
- Fink K, Zellweger R, Weber J, Manjarrez-Orduno N, Holdener M, Senn BM, Hengartner H, Zinkernagel RM, Macpherson AJ. “Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.” Eur J Immunol. 2008 an;38(1):90-101. PubMed PMID: 18081043.
- Fink K, Manjarrez-Orduño N, Schildknecht A, Weber J, Senn BM, Zinkernagel RM, Hengartner H. “B cell activation state-governed formation of germinal centers following viral infection.” J Immunol. 2007 Nov 1;179(9):5877-85. PubMed PMID:17947661.
- Manjarrez-Orduño N, Moreno-García ME, Fink K, Santos-Argumedo L. “CD38 cross-linking enhances TLR-induced B cell proliferation but decreases IgM plasma cell differentiation.” Eur J Immunol. 2007 Feb;37(2):358-67. PubMed PMID: 17274001.
- Fink K, Lang KS, Manjarrez-Orduno N, Junt T, Senn BM, Holdener M, Akira S, Zinkernagel RM, Hengartner H. “Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.” Eur J Immunol. 2006 Aug;36(8):2094-105. PubMed PMID: 16810635.
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