Sharon A. Singh, MD

Dr. Sharon Singh received her medical degree from Mount Sinai School of Medicine. After residency training in pediatrics, she joined Cohen Children’s Medical Center in 2005, where she completed a pediatric hematology/oncology fellowship.  During her fellowship, she was awarded the very first St. Baldrick’s Foundation Fellowship Award to study the mechanism of cancer predisposition in Diamond Blackfan Anemia using mouse embryonic stem cells.

After fellowship, she was appointed Assistant Professor of Pediatrics at the Hofstra North Shore-LIJ School of Medicine and was Interim Director of the Sickle Cell Program at Cohen Children’s Medical Center until 2012.  During that time she was site PI of two multicenter sickle cell stroke clinical trials. Dr. Singh was awarded a St. Baldrick’s Foundation Career Development Award in 2010 to study the role of p53 in Diamond Blackfan Anemia. She is a guest reviewer for PLOS ONE and has reviewed grants for St. Baldrick’s Foundation since 2011.

Dr. Singh heads the Laboratory of Pediatric Cancer Mechanisms.  Her team is focused on elucidating the pathway(s) responsible for the cancer predisposition in patients with bone marrow failure syndromes.  The reason(s) for an increased risk of developing cancer in the setting of ribosomal protein deficiency is currently unknown. Previous work established mouse embryonic stem cells as a robust model to study Diamond Blackfan anemia (DBA).  DBA is one of the inherited bone marrow failure syndromes caused in the majority of cases by ribosomal protein haploinsufficiency.  Her laboratory is now also engaged in determining the impact of ribosomal protein haploinsufficiency on the immune system.

New York University, New York, NY
Degree: BA
1997
Field of Study: Chemistry

Mount Sinai School of Medicine, New York, NY
Degree: MD
2001
Field of Study: Internal Medicine

Schneider Children’s Hospital at North Shore, Manhasset, NY
Degree: Residency
2004
Field of Study: Pediatrics

Steven and Alexandra Cohen Children’s Medical Center of New York, New Hyde Park, NY
Degree: Residency
2004
Field of Study: Pediatrics

1997 Cum Laude, New York University
1998 Summer Research Scholars Program, Mount Sinai School of Medicine
1998-1999 President of Student National Medical Association, Mount Sinai chapter
1999 Lippincott, Williams and Wilkins Book Award for outstanding medical student in Community Service, Mount Sinai School of Medicine
1999-2000 Student Advisory Board, Mount Sinai School of Medicine, Cultural Diversity in Medicine course
2005-2008 St Baldrick’s Foundation Fellowship Award
2011-2012 selected for NHLBI funded PRIDE Program-Functional and Applied Genomics of Blood Disorders Section
2010-2015 St Baldrick’s Foundation Career Development Award

1. Singh SA, Goldberg TA, Henson AL, Husain-Krautter S, Nihrane A, et al. (2014) “p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.” PLoS One 9: e89098.
2. Vlachos A, Farrar JE, Atsidaftos E, Muir E, Narla A, Markello T, Singh SA, et al. (2013) “Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome.” Blood 122: 2487-90.
3. Sezgin G, Henson AL, Nihrane A, Singh S, Wattenberg M, et al. (2013) “Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS.” Pediatr Blood Cancer 60: 281-286.
4. Singh SA, Vlachos A, Morgenstern NJ, Ouansafi I, Ip W, et al. (2011) “Breast cancer in a case of Shwachman Diamond syndrome.” Pediatr Blood Cancer 59: 945-6.
5. Ware RE, Helms RW, Investigators S^* (2012) “Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)”. Blood 119: 3925-3932 (*member of the SWiTCH investigative team cited in the appendix of the manuscript).

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