Joshua W. Lampe, PhD

Dr. Lampe has dedicated his career to the research and development of new technologies to monitor and treat cardiac arrest. One of his principle research foci has been to better understand chest compression generated blood flow. The research that he has conducted has shown that chest compression depth can be related to coronary perfusion pressure, and that our kinematic description of chest compression is incomplete. The current focus of this effort is on improving the amount of forward blood flow generated by chest compression.

Thermokinetics of Therapuetic Hypothermia:

Dr. Lampe’s research into the thermokinetics of therapeutic hypothermia has focused on the creation and characterization of devices to create an ice particulate saline slurry for medical cooling applications. His research has elucidated the presence of significant temperature gradients in the body when cooling is initiated during ongoing cardiac arrest or CPR.

Metabolic Derangement:
Dr. Lampe’s research into metabolic derangement after resuscitation from cardiac arrest has focused on understanding mitochondrial alterations after ischemia/reperfusion injury as well as inflammatory/biochemical alterations after reperfusion. This effort has highlighted complex 1 in the mitochondrial electron transport chain as a site susceptible to alteration after reperfusion as well as the presence of highly unexpected metabolic byproducts (e.g. lysophospholipids, bile salts) after prolonged ischemia.

Tulane University
Degree: Bachelor of Arts
Field of Study: History
1998

University of Massachusetts, Amherst
Degree: Bachelor of Science
Field of Study: Mechanical Engineering
2003

University Of Pennsylvania
Degree: PhD
Field of Study: Mechanical Engineering
2007

Hospital of the University of Pennsylvania
Degree: Postdoctoral Fellow
Field of Study: Resuscitation Science
2012

2002 Undergraduate Research Fellowship, University of Massachusetts, Amherst
2004-2005 John A. Goff Prize, University of Pennsylvania
2009-2011 NIH Clinical LRP Award, NHLBI
2014 Cournand and Comroe Young Investigator Finalist, American Heart Association

1. Naim MY, Sutton RM, Friess SH, Bratinov G, Bhalala U, Kilbaugh TJ, Lampe JW, Nadkarni VM, Becker LB, Berg RA. Blood Pressure- and Coronary Perfusion Pressure-Targeted Cardiopulmonary Resuscitation Improves 24-Hour Survival From Ventricular Fibrillation Cardiac Arrest. Crit Care Med. 2016 Nov;44(11):e1111-e1117. PubMed PMID: 27414479; PubMed Central PMCID: PMC5069077.
2. Lampe JW, Tai Y, Bratinov G, Weiland TR, Kaufman CL, Berg RA, Becker LB. Developing a kinematic understanding of chest compressions: the impact of depth and release time on blood flow during cardiopulmonary resuscitation. Biomed Eng Online. 2015 Nov 4;14:102. PubMed PMID: 26537881; PubMed Central PMCID: PMC4634731.
3. Sutton RM, Friess SH, Naim MY, Lampe JW, Bratinov G, Weiland TR 3rd, Garuccio M, Nadkarni VM, Becker LB, Berg RA. Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest. Am J Respir Crit Care Med. 2014 Dec 1;190(11):1255-62. PubMed PMID: 25321490; PubMed Central PMCID: PMC4315818.
4. Lampe JW, Bratinov G, Weiland TR 3rd, Illindala U, Berg RA, Becker LB. Volume infusion cooling increases end-tidal carbon dioxide and results in faster and deeper cooling during intra-cardiopulmonary resuscitation hypothermia induction. Intensive Care Med Exp. 2015 Dec;3(1):37. PubMed PMID: 26715581; PubMed Central PMCID: PMC4695470.
5. Lampe J, Bull D, Becker L. RAPID INDUCTION OF HETEROGENEOUS ICE NUCLEATION IN A BIOLOGICALLY COMPATIBLE COOLANT. Int J Transp Phenom. 2011;12(3-4):307-317. PubMed PMID: 25954121; PubMed Central PMCID: PMC4420239.
6. Lampe JW, Becker LB. State of the art in therapeutic hypothermia. Annu Rev Med. 2011;62:79-93. PubMed PMID: 20854174; PubMed Central PMCID: PMC4565599.
7. Boller M, Lampe JW, Katz JM, Barbut D, Becker LB. Feasibility of intra-arrest hypothermia induction: A novel nasopharyngeal approach achieves preferential brain cooling. Resuscitation. 2010 Aug;81(8):1025-30. PubMed PMID: 20538402; PubMed Central PMCID: PMC4565604.
8. Kim J, Villarroel JP, Zhang W, Yin T, Shinozaki K, Hong A, Lampe JW, Becker LB. The Responses of Tissues from the Brain, Heart, Kidney, and Liver to Resuscitation following Prolonged Cardiac Arrest by Examining Mitochondrial Respiration in Rats. Oxid Med Cell Longev. 2016;2016:7463407. PubMed PMID: 26770657; PubMed Central PMCID: PMC4685127.
9. Kim J, Lampe JW, Yin T, Shinozaki K, Becker LB. Phospholipid alterations in the brain and heart in a rat model of asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation. Mol Cell Biochem. 2015 Oct;408(1-2):273-81. PubMed PMID: 26160279; PubMed Central PMCID: PMC4573890.
10. Kilbaugh TJ, Sutton RM, Karlsson M, Hansson MJ, Naim MY, Morgan RW, Bratinov G, Lampe JW, Nadkarni VM, Becker LB, Margulies SS, Berg RA. Persistently Altered Brain Mitochondrial Bioenergetics After Apparently Successful Resuscitation From Cardiac Arrest. J Am Heart Assoc. 2015 Sep 14;4(9):e002232. PubMed PMID: 26370446; PubMed Central PMCID: PMC4599507.
11. Shinozaki K, Lampe JW, Wang CH, Yin T, Kim J, Oda S, Hirasawa H, Becker LB. Developing dual hemofiltration plus cardiopulmonary bypass in rodents. J Surg Res. 2015 May 1;195(1):196-203. PubMed PMID: 25555403.